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细胞药物中心
大健康研究院 研究员
个人简介：
李凤琦，女，2012年毕业于中国科学技术大学生命科学学院并获得博士学位；2012-2014年在中国科学技术大学从事博士后研究工作，主要研究方向为肺脏区域免疫特性与呼吸道疾病；2014-2022年在瑞士苏黎世联邦理工学院分子健康科学研究所Manfred Kopf教授实验室从事博士后研究，2022年10月全职加入大健康研究院，并成立肺脏免疫学实验室。主要研究方向为以肺泡巨噬细胞为主的肺脏区域免疫与肺脏疾病。已发表学术论文20余篇，以第一作者/或通讯作者身份在Science Immunology （2022），EMBO J（2020）, JEM （2014），Nature Communications （2013）， JCI insight（2022），Front Immunol（2023，2025）等杂志发表论文9篇，以共作者身份在Cell, Nat Immunol, Immunity，Cell Metab, Cell Rep和 J. Allergy Clin. Immunol等杂志发表论文10篇。入选2023年国家级人才项目和安徽省重点人才项目，主持国自然重大研究计划培育项目及国自然面上项目，参与国家科技重大专项等项目。
研究兴趣及方向：
主要致力于探索重大呼吸系统疾病的免疫学机理以及治疗策略。主要研究方向为: 1）不同肺脏微环境对肺泡巨噬细胞（AM）发育和功能的影响; 2）以AM为中心的细胞间相互作用网络与肺脏疾病的关联; 3）中医复方调控AM治疗慢性炎症性肺疾病的机制研究；4）AM的高效分化扩增和基因编辑改造。主要转化方向为：功能性AM细胞药物研发及基于AM的肺脏重大疾病的免疫治疗策略。
代表性工作：
1. Wang J, Qiu Y, Marti Z, Li F, Wacker M, Oldrati P, Mühlenbruch L, Jin L, Zhang H, Xu W, Li T, Roschitzki B, Faigle W, Liu Y, Nguyen JT, Lee JH, Haunerdinger V, Hauri-Hohl M, Momburg F, Bauer J, Rammensee HG, Sospedra M, Magliozzi R, Reynolds R, Walz J, Martin R. EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation. Cell. 2026. Jan 22;1892:569-584.e14.
2. Ren M, Dou J, Yue Q, Ma L, Yu H, Shang S, Wang S, Wang J#, Li T#, Li F#. Alveolar macrophages maintain tissue localization and gain enhanced anti-tumor activity in Lewis lung carcinoma-reprogrammed lung microenvironment. Front. Immunol. 2025. Jul 24;16:1616514.
3. Matsushita M, Muri J, Berest I, Li F, Liu H, Corak B, Zamboni N, Buescher J, Othman A, Corrado M, Cupovic J, Werner S, Kovacs W, Kopf M. Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages. Cell Rep. 2025. Apr 25;445:115623.
4. Zhang J, Sj?berg KA, Gong S, Wang T, Li F, Kuo A, Durot S, Majcher A, Ardicoglu R, Desgeorges T, Mann CG, Soro Arnáiz I, Fitzgerald G, Gilardoni P, Abel ED, Kon S, Olivares-Villagómez D, Zamboni N, Wolfrum C, Hornemann T, Morscher R, Tisch N, Ghesquière B, Kopf M, Richter EA, De Bock K. Endothelial metabolic control of insulin sensitivity through resident macrophages. Cell Metab. 2024. Nov 5;3611:2383-2401.e9.
5. Iliakis CS, Kulikauskaite J, Aegerter H, Li F, Piattini F, Jakubzick CV, Guilliams M, Kopf M, Wack A. The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function. Nat Immunol. 2023. Oct;2410:1639-1641.
6. Zhang, H, Wang, J# and Li, F.# Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment. Front. Immunol. 2023. Nov 6:14:1286986
7. Li, F.*, Piattini, F.*, Pohlmeier, L., Qian, F., Rehrauer, H., Kopf, M.# Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection. Sci Immunol. 2022. 7, eabj5761.
8. Li, F.*, Okreglicka, K.*, Piattini, F., Pohlmeier, L., Schneider, C., Kopf, M.# Gene therapy of Csf2ra-deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and function. JCI insight. 2022. 7 7: e152271.
9. Li, F., Okreglicka, K., Pohlmeier, L., Schneider, C., Kopf, M.# Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development. EMBO J. 2020. 39 3 e103205.
10. Nobs, S., Pohlmeier, L., Li, F., Kayhan, M., Becher, B., Kopf, M.# GM-CSF instigates a dendritic cell–T-cell inflammatory circuit that drives chronic asthma development. J. Allergy Clin. Immunol. 2021. 147 6, 2118-2133.e3.
11. Huang, C., Li, F., Wang, J.#, Tian, Z.# Innate-like lymphocytes and innate lymphoid cells in asthma. Clin Rev Allergy Immunol. 2020. 59 3359-370.
12. Minutti, C. M.*, Modak, R. V.*, Macdonald, F., Li, F., Smyth, D. J., Dorward, D. A., Blair, N., Husovsky, C., Muir, A., Giampazolias, E., Dobie, R., Maizels, R. M., Kendall, T. J., Griggs, D. W., Kopf, M., Henderson, N. C., Zaiss, D. M.# A macrophage-pericyte axis directs tissue restoration via amphiregulin-induced transforming growth factor beta activation. Immunity. 2019. 50 3 645-654.e6.
13. Wang, J.#, Li, F., and Tian, Z.#. Role of microbiota on lung homeostasis and diseases. Sci China Life Sci. 2017. 6012:1407-1415.
14. Wang, J., Li, F., Sun, R., Gao, X., Wei, H., and Tian, Z.# Klebsiella pneumoniae alleviates influenza-induced acute lung injury via limiting NK cell expansion. J Immunol. 2014. 1933, 1133-1141.
15. Wang, J.*, Li, F.*, Wei, H., Lian, Z.X., Sun, R., and Tian, Z.# Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. J Exp Med. 2014. 21112, 2397-2410.
16. Wang, J.*, Li, F.*, Sun, R., Gao, X., Wei, H., Li, L.J., and Tian, Z.# Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun. 2013. 4, 2106. *Co-first author
17. Wang, J., Li, F., Zheng, M., Sun, R., Wei, H., and Tian, Z.# Lung natural killer cells in mice: phenotype and response to respiratory infection. Immunology. 2012. 137 1, 37-47.
18. Li, F., Zhu H., Sun, R., Wei, H., and Tian, Z.# Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection. J Virol. 2012. 86 4: 2251-8.
