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细胞药物中心
副研究员
个人简介：
2018年6月毕业于山东大学并获得博士学位，2018年9月至2022年12月在美国The Jackson Laboratory从事博士后研究工作。研究生期间主要从事胰岛稳态和糖代谢方面的研究，博士后期间主要从事肿瘤免疫和脂质代谢方面的研究。目前以第一作者含共同身份在Immunity, Cell Metabolism, Science Immunology, Journal of Clinical Investigation, Diabetologia, Cell Death & Disease等杂志发表论文7篇。2023年1月加入合肥综合性国家科学中心大健康研究院。
研究兴趣及方向：
1. 研究糖脂代谢对免疫细胞功能稳态的调控作用。
2. 探索基于细胞代谢重编程的重大疾病的干预策略。
代表性工作：
1. Zheng Gong#, Qing Li#, Jiayuan Shi, Peishan Li, Li Hua, Leonard D. Shultz, Guangwen Ren. Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis. Science Immunology. 2023 Feb 24;880:eadd5204.. # Co-first author.
2. Zheng Gong#, Qing Li#, Jiayuan Shi, Edison T Liu, Leonard D Shultz, Guangwen Ren. Lipid-Laden Lung Mesenchymal Cells Foster Breast Cancer Metastasis via Metabolic Reprogramming of Tumor Cells and Natural Killer Cells. Cell metabolism. 2022 Dec 6;3412:1960-1976.e9. # Co-first author.
3. Zheng Gong#, Qing Li#, Jiayuan Shi, Jian Wei, Peishan Li, Chih-Hao Chang, Leonard D Shultz, Guangwen Ren. Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment. Immunity. 2022 Aug 9;558:1483-1500.e9 # Co-first author.
4. Na Li#, Zhao Yang#, Qing Li#, Zhen Yu, Xu Chen, Jia-Cheng Li, Bo Li, Shang-Lei Ning, Min Cui, Jin-Peng Sun, Xiao Yu. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death & Disease.2018 Jun 7;96:682. # Co-first author.
5. Qing Li#, Min Cui#, Fan Yang#, Na Li, Baichun Jiang, Zhen Yu, Daolai Zhang, Yijing Wang, Xibin Zhu, Huili Hu, Pei-Shan Li, Shang-Lei Ning, Si Wang, Haibo Qi, Hechen Song, Dongfang He, Amy Lin, Jingjing Zhang, Feng Liu, Jiajun Zhao, Ling Gao, Fan Yi, Tian Xue, Jin-Peng Sun, YaoqinGong, Xiao Yu. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. Journal of Clinical Investigation. 2017 Jun 30;1277:2631-2646. # Co-first author.
6. Hong-Mei Wang#, Jun-Hong Dong#, Qing Li#, Qiaoxia Hu, Shang-Lei Ning, Wenshuai Zheng, Min Cui, Tian-Sheng Chen, Xin Xie, Jin-Peng Sun, Xiao Yu. A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1. Diabetologia. 2014 Sep;579:1899-910.. # Co-first author.
