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慢性疾病药物中心
大健康研究院 研究员
个人简介：
公丽岩，2014年毕业于吉林大学，获学士学位；2020年毕业于中国科学院分子细胞科学卓越创新中心（原生化与细胞所），获博士学位。2020年10月至2021年12月于同济大学医学院进行博士后训练，并于2022年1月至2025年9月于美国哈佛医学院/波士顿儿童医院（Harvard Medical School/ Boston Children’s Hospital）从事博士后研究。2025年11月回国加入合肥综合性国家科学中心大健康研究院担任研究员。主要研究方向聚焦于干细胞与类器官技术的开发和应用。以第一作者身份（含共同）在Cell Stem Cell、Cell Discovery、Journal of Clinical Investigation、Frontiers in Cell and Developmental Biology等期刊上发表多篇SCI研究论文。
研究兴趣及方向：
我们致力于利用干细胞与类器官技术构建高保真的人类疾病模型。以自建的快速血管类器官体系为核心，研究血管发育调控、肿瘤微环境中的血管异常及肿瘤-血管互作机制，并发展肿瘤类器官和免疫细胞等多类型模型与血管系统的耦合体系，以模拟更复杂的病理过程。结合基因编辑、空间转录组和多尺度成像等手段，系统解析疾病相关的关键调控网络。在此基础上，研究组探索类器官模型在抗肿瘤药物评价、靶点验证、免疫治疗响应预测及血管异常疾病模拟等方面的应用潜力，构建兼具机制深度与转化价值的类器官平台。同时推动建立符合GMP要求的三维培养体系和标准化细胞库，为未来临床应用与产业化奠定基础。
代表性工作：
1.Gong, L., Zhang, Y., Zhu, Y., Lee, U., Luo, A. C., Li, X., Wang, X., Chen, D., Pu, W. T., Lin, R., Ma, M., Cui, M., Chen, K., Wang, K.#, Melero-Martin, J. M#. 2025. Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages. Cell Stem Cell, 32, 1-18. Cover Story
2. Gong, L., Wang K., Wang M., Hu R., Li H., Gao D. #, and Lin M#. 2021. CUL5-ASB6 complex promotes p62/SQSTM1 ubiquitination and degradation to regulate cell proliferation and autophagy. Front. Cell Dev. Biol. 9:684885.
3.Cui, B.*, Gong, L.*, Chen, M., Zhang, Y., Yuan, H., Qin, Jun, and Gao, D#. 2019. CUL5-SOCS6 complex regulates mTORC2 function by targeting Sin1 for degradation. Cell Discovery.
4.Zhao, G. *, Gong, L. *, Su, D.*, Jin, Y., Guo, C., Yue, M., Yao, S., Qin, Z., Ye, Y., Tang, Y., Wu, Q., Zhang, J., Cui, B., Ding, Q., Huang, H., Hu, L., Chen, Y., Zhang, P., Hu, G., Chen, L., Wong, K.K., Gao, D. #, and Ji, H#. 2019. Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta1. J Clin Invest 129, 972-987.
5. Li, X. *, Kim, H. D. *, Luo, A. C., Gong, L., Lee, C., Hong, X., Sudduth, C. L., Ad, M., An, Young., Park, M., Kim, D., Greene, A.K., Padwa, B.L., Hwang, N.S., Lin, R., Melero-Martin, J. M#. Human bone-derived endothelial cells mediate bone regeneration via distinct expression of KIT ligand. Advanced Science, 2025, e14194.
6. Chen, D., Fan, X., Sun, N., Wang, K., Gong, L., Melero-Martin, J. M., & Pu, W. T#. Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. Nature Cardiovascular Research. 2025 Jun;46:689-709.
7. Lee, U. *, Zhang, Y. *, Zhu, Y., Luo, A. C., Gong, L., Tremmel, D. M., Kim, Y., Villarreal, V. S., Wang, X., Lin, R.-Z., Cui, M., Ma, M., Yuan, K., Wang, K. #, Chen, K. #, & Melero-Martin, J. M#. 2024. Robust differentiation of human pluripotent stem cells into mural progenitor cells via transient activation of NKX3.1. Nature Communications, 15, 8392.
8. Luo, A. C., Wang, J., Wang, K., Zhu, Y., Gong, L., Lee, U., ... & Melero-Martin, J. M#. 2024. A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation. Angiogenesis, 1-17.
9.Hu, H. *, Zhu, W. *, Qin, J., Chen, M., Gong, L., Li, L., Liu, X., Tao, Y., Yin, H., Zhou, H., Zhou, L., Ye, D., Ye, Q., and Gao, D#. 2017. Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis. Hepatology Baltimore, Md 65, 515-528.
10.Liu, X., Chen, M., Li, L., Gong, L., Zhou, H., and Gao, D#. 2017. Extracellular Signal-regulated Kinases ERKs Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Differentiation. The Journal of Biological Chemistry 292, 3970-3976.
