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技术团队
高级工程师
个人简介：
许威亚，女，2010年美国奥本大学（Auburn University）化学与生物化学系博士毕业，博士阶段主要致力于铁硫簇类固氮酶的机理研究。2010年至2014年于美国弗吉尼亚理工大学从事博士后研究，主要研究铁硫簇的生物合成及传输机理。2018年至2023年在中国科学技术大学生命科学学院担任特任副研究员，主要从事生物大分子的动态组装研究。近五年，在Nature Structural & Molecular Biology、Nature Communications、Cell Discovery等国际主流期刊上发表多篇研究论文。
研究兴趣及方向：
负责大健康研究院AI辅助新药创制平台的建设与运行，以免疫治疗为特色优势，搭建 AI 全链条新药研发体系，形成“AI 设计 — 高通量湿筛 — 模型迭代”飞轮研发模式，布局细胞药物、小分子靶向药、特色抗体、核酸、微生物治疗几大类新药研发。AI辅助新药创制平台将满足研究院内部科研团队或外部合作单位的相关需求，助力新药研发和转化。
代表性工作：
1. Yanshen Zhang*, Weiya Xu*, Wenxiu Duan*, Yu Wei,Wenli Jiang, Feng Zhu, Chengdong Huang #, Chao Wang #, Yihui Bi #. MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase Separation. eLife. 202514:RP108479.
2. Xiaozhan Qu*, Simin Wang, Shuo Zhao, Chanjuan Wan, Weiya Xu#, Chengdong Huang#. The dynamic triage interplay of Hsp90 with its chaperone cycle and client binding. Nature Communications 2024 15:10661.
3. Xiaozhan Qu*, Shuo Zhao, Chanjuan Wan , Lei Zhu?, Tuo Ji, Paolo Rossi, Junfeng Wang, Charalampos G. Kalodimos, Chao Wang, Weiya Xu#, Chengdong Huang#. Structural basis for the dynamic chaperoning of disordered clients by Hsp90. Nature Structural & Molecular Biology. 202431:1482–1491.
4. Hang Li*, Tuo Ji, Qi Sun, Yao Chen, Weiya Xu# and Chengdong Huang#. Structural insights into ive inhibition ofmleishmanial GDP-mannose pyrophosphorylase. Cell Discovery. 2022 8:83.
5. Yao Chen*, Weiya Xu*, Shuwei Yu*, Kang Ni, Guangbiao She, Xiaodong Ye, Qiong Xing#, Jian Zhao#, Chengdong Huang#. Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme. eLife 202110:e72535.
6. Lin Huang*, Xiaozhan Qu, Yao Chen, Weiya Xu#, Chengdong Huang#. Sandwiched-fusion strategy facilitates recombinant production of small labile proteins. Protein Science. 202130:650–662.
7. Weiya Xu*, Nicholas S. Lees, Dominique Hall, Dhanushi Welideniya, Brian M. Hoffman, Evert C. Duin#. A Closer Look at the Spectroscopic Properties of Possible Reaction Intermediates in Wild-Type and Mutant E-4-Hydroxy-3-methylbut-2-enyl Diphosphate Reductase. Biochemistry. 201251:4835?4849.
8. Weiya Xu*, Nicholas S. Lees, Dolapo Adedeji, Jochen Wiesner, Hassan Jomaa, Brian M. Hoffman, and Evert C. Duin#. Paramagnetic Intermediates of E-4-Hydroxy-3-methylbut-2-enyl Diphosphate SynthaseGcpE/IspG under Steady-State and Pre-Steady-State Conditions. J. AM. CHEM. SOC. 2010 132:14509–14520.
